Imidazole → 1-(3,4-Dichlorophenyl)-4-(3-iodopropyl)piperazine

HRID 64219Notes

Reaction equation

HRID 64219 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17]O)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.N1C=CN=C1.[I:43]I>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][I:43])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 807IodineHCID 11776TriphenylphosphineHCID 130979303-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol

Product 1

HCID 680069941-(3,4-Dichlorophenyl)-4-(3-iodopropyl)piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 7p was mixed with triphenylphosphine resin, imidazole and iodine in DCM as described in General Procedure B. The product compound 11p was used without further purification for the next reaction. MS (LC/MS, ESI): 399 (M+H).

Workup

  1. customThe product compound 11p was used without further purification for the next reaction

Sources & evidence

ORD record
ord-19cbbae58e7f411182f1a9ece29fe70c
Source dataset
uspto-grants-2016_09
Patent number
US09447122B2

Reaction notes

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