Hydrochloric Acid → HCID 68577659, compound

HRID 642202Notes

Reaction equation

HRID 642202 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:21][CH2:20][CH2:19][C@H:18]2[CH2:22][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:16])=[CH:11][CH:10]=1.[ClH:28]>C(OCC)C.CO>[ClH:28].[ClH:28].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:21][CH2:20][CH2:19][C@H:18]2[CH2:22][N:23]2[CH2:24][CH2:25][CH2:26][CH2:27]2)=[O:16])=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11617548HCID 11617548, compound

Product 1

HCID 68577659HCID 68577659, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of [4-(Pyridin-2-ylmethoxy)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone (1.94 g, 5.3 mmol) in diethyl ether and methanol is added a solution of HCl in ether (10.7 mmol, 1M). The mixture is concentrated, and the oily residue is dissolved in a mixture of diethyl ether and methanol and again concentrated. The solid is triturated with petroleum ether, and the solid is dried to yield 2.2 g of a yellowish solid MS (ES+) 1366.3

Workup

  1. concentrationThe mixture is concentrated
  2. dissolutionthe oily residue is dissolved in a mixture of diethyl ether and methanol
  3. concentrationagain concentrated
  4. customThe solid is triturated with petroleum ether
  5. customthe solid is dried

Sources & evidence

ORD record
ord-54c7643fdf42407fa1ea3749d1a5a762
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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