Hydrochloric Acid → HCID 68577806, compound

HRID 642203Notes

Reaction equation

HRID 642203 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:22][CH2:21][CH2:20][C@H:19]1[CH2:23][N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:17].[ClH:29].O1CCOCC1>CO>[ClH:29].[ClH:29].[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:22][CH2:21][CH2:20][C@H:19]1[CH2:23][N:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1)=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 11639561HCID 11639561, compound

Product 1

HCID 68577806HCID 68577806, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [2-Fluoro-4-(pyridin-2-ylmethoxy)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone (0.386 g, 1 mmol) in methanol (3 mL) is added a solution of 4M HCl in dioxane (2 mmol). The mixture is concentrated, and the oily residue is dissolved in CH2Cl2 and again concentrated and dried. MS (ES+) 384

Workup

  1. concentrationThe mixture is concentrated
  2. dissolutionthe oily residue is dissolved in CH2Cl2
  3. concentrationagain concentrated
  4. customdried

Sources & evidence

ORD record
ord-5532e30c5cc64b64aa82ee2373772bf8
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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