HRID642505
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A mixture of [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid (50 mg), Zn(CN)2 (9.0 mg), Zn dust (1.0 mg), Pd2(dba)3 (5.9 mg), dppf (7.1 mg) in DMA (1 mL) was heated to 120° C. for 60 min; then the mixture was cooled, diluted with DMSO and purified by C18 reverse phase chromatography to give the desired title compound (33 mg). The title compound, ESI MS (m/z): 337 (M+H)+.
WORKUP
后处理
- temperaturethen the mixture was cooled
- custompurified by C18 reverse phase chromatography