Lithium Hydroxide → HCID 68675578, compound

HRID 643146Notes

Reaction equation

HRID 643146 reaction equation
[Li+].[OH-].[CH2:3]([O:10][C:11]1[C:43]([CH3:44])=[CH:42][C:14]([CH2:15][C@@H:16]([CH2:21][C:22](=[O:41])[N:23]2[CH2:28][CH2:27][CH:26]([N:29]3[CH2:35][CH2:34][C:33]4[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=4[NH:31][C:30]3=[O:40])[CH2:25][CH2:24]2)[C:17]([O:19]C)=[O:18])=[CH:13][C:12]=1[CH3:45])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O.C1COCC1>[CH2:3]([O:10][C:11]1[C:43]([CH3:44])=[CH:42][C:14]([CH2:15][C@@H:16]([CH2:21][C:22](=[O:41])[N:23]2[CH2:28][CH2:27][CH:26]([N:29]3[CH2:35][CH2:34][C:33]4[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=4[NH:31][C:30]3=[O:40])[CH2:25][CH2:24]2)[C:17]([OH:19])=[O:18])=[CH:13][C:12]=1[CH3:45])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 69068234HCID 69068234, compound

Product 1

HCID 68675578HCID 68675578, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 200 mg (8.35 mmol) LiOH in 40 mL water was added to a solution of 2.43 g (4.16 mmol) methyl (S)-2-(4-benzyloxy-3,5-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoate in 80 mL THF and the reaction mixture was stirred for 1 h at RT. The mixture was evaporated down i.vac., the residue was taken up in 100 mL water and acidified with 2 M HCl with stirring. The precipitate formed was separated off and dried at 40° C.

Workup

  1. customThe mixture was evaporated down i.vac
  2. stirringwith stirring
  3. customThe precipitate formed
  4. customwas separated off
  5. customdried at 40° C.

Sources & evidence

ORD record
ord-9a413b994a654b6994c541054416e559
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

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