反应详情

To a solution of benzylamine (0.125 mmol) in 5 mL of THF is added diisopropylethyl amine (0.15 mmol) and benzoylchloride (0.10 mmol). The reaction mixture is stirred at room temperature for 1 hour or until TLC analysis shows consumption of the benzoyl chloride. To this mixture is added perfluorsulfonic acid resin prepared in example 8 (3 g, 0.3 mmol/g loading) and the slurry is gently agitated for 1 hour. The slurry is filtered and the resin washed with dichloromethane. The combined filtrates are combined and the solvent removed under reduced pressure to afford N-benzylbenzamide as a solid.

1. customconsumption of the benzoyl chloride
2. additionTo this mixture is added perfluorsulfonic acid resin prepared in example 8 (3 g, 0.3 mmol/g loading)
3. stirringthe slurry is gently agitated for 1 hour
4. filtrationThe slurry is filtered
5. washthe resin washed with dichloromethane
6. customthe solvent removed under reduced pressure