反应详情

A solution of 3-benzyl-8-trifluoromethyl-cinnolin-4-ol (1.6 g, 4.4 mmol) and POBr3 (2.5 g, 8.7 mmol) in DMF (30 ml) was heated to 75° C. After 1 hr, the reaction was cooled and poured into water. The aqueous layer was extracted with EtOAc which was dried (MgSO4) and concentrated to give a solid. The solid was triturated with MeOH and filtered to give 3-benzyl-4-bromo-8-trifluoromethyl-cinnoline (1.7 g). MS (ES) m/z 366.7.

1. temperaturethe reaction was cooled
2. extractionThe aqueous layer was extracted with EtOAc which
3. dry with materialwas dried (MgSO4)
4. concentrationconcentrated
5. customto give a solid
6. customThe solid was triturated with MeOH
7. filtrationfiltered