反应详情

A mixture of 4-chlorophenylguanidine carbonate (644 mg), 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (373 mg), sodium carbonate (495 mg), palladium (II) acetate (14 mg) and tricyclohexylphosphine (19 mg) in water (1.2 ml) and dioxane (5.7 ml) is kept at 100° C. under micro wave conditions for 200 min. The mixture is cooled down to rt, basified with 1 N NaOH to pH 10.5 and extracted 4 times with EtOAc. The combined organic phases are washed with brine and dried over sodium sulfate. The solvent is evaporated to afford crude N-(3′-hydroxy-biphenyl-4-yl)guanidine.

1. extractionextracted 4 times with EtOAc
2. washThe combined organic phases are washed with brine
3. dry with materialdried over sodium sulfate
4. customThe solvent is evaporated