HCID 59261072, compound → HCID 59261064, compound

HRID 643545Notes

Reaction equation

HRID 643545 reaction equation
[C:1]([O:4][CH:5]([C:7]1([C:16]([NH:18][CH2:19][C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=2[O:30]C(C)(C)C)=[O:17])[CH2:11][CH2:10][CH:9]([O:12][C:13](=[O:15])[CH3:14])[CH2:8]1)[CH3:6])(=[O:3])[CH3:2]>Cl.O1CCOCC1>[C:13]([O:12][CH:9]1[CH2:10][CH2:11][C:7]([CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH3:6])([C:16]([NH:18][CH2:19][C:20]2[CH:25]=[C:24]([C:26]([F:27])([F:29])[F:28])[CH:23]=[CH:22][C:21]=2[OH:30])=[O:17])[CH2:8]1)(=[O:15])[CH3:14]

Participants

4

Reactant 1

HCID 59261072HCID 59261072, compound

Product 1

HCID 59261064HCID 59261064, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

1-[3-(Acetyloxy)-1-({[2-tert-butoxy-5-(trifluoromethyl)benzyl]amino}carbonyl)cyclopentyl]ethyl acetate (7.0 g, 14.4 mmol) was dissolved in anhydrous 4N HCl in dioxane (40 mL) and stirred at rt for 65 min. The reaction mixture was then concentrated to give 3-[1-(acetyloxy)ethyl]-3-({[2-hydroxy-5-(trifluoromethyl)benzyl]amino}carbonyl)cyclopentyl acetate.

Workup

  1. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-8b92dcb888594c7cbe6b350b77e05a95
Source dataset
uspto-grants-2010_04
Patent number
US07700591B2

Reaction notes

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