Hydrochloric Acid → HCID 86604120, compound

HRID 643551Notes

Reaction equation

HRID 643551 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C:12]2[CH:16]=[C:15]([CH:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[O:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:30]>O1CCOCC1>[ClH:30].[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C:12]2[CH:16]=[C:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[O:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59261033HCID 59261033, compound

Product 1

HCID 86604120HCID 86604120, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-(3-{[(4-methylphenyl)sulfonyl]oxy}isoxazol-5-yl)piperidine-1-carboxylate (719 mg, 1.76 mmol) was dissolved in anhydrous 4N HCl in dioxane (15 mL) and the resulting solution was stirred at rt for 1 h. The reaction mixture was concentrated to afford 5-piperidin-4-ylisoxazol-3-yl 4-methylbenzenesulfonate hydrochloride, which did not require further purification.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d5b30b1b7fab4d8ca2a470df4de906f5
Source dataset
uspto-grants-2010_04
Patent number
US07700591B2

Reaction notes

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