Hydrochloric Acid → HCID 86604121, compound

HRID 643560Notes

Reaction equation

HRID 643560 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C:12]2[C:16]3[CH:17]=[C:18]([CH:21]4[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]4)[CH:19]=[CH:20][C:15]=3[O:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:34]>O1CCOCC1>[ClH:34].[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C:12]2[C:16]3[CH:17]=[C:18]([CH:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)[CH:19]=[CH:20][C:15]=3[O:14][N:13]=2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59261016HCID 59261016, compound

Product 1

HCID 86604121HCID 86604121, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-(3-{[(4-methylphenyl)sulfonyl]oxy}-1,2-benzisoxazol-5-yl)piperidine-1-carboxylate (285 mg, 0.603 mmol) was dissolved in anhydrous 4N HCl in dioxane (6 mL) and the resulting mixture was stirred at rt for 1 h. The reaction mixture was concentrated to afford 5-piperidin-4-yl-1,2-benzisoxazol-3-yl 4-methylbenzenesulfonate hydrochloride which did not require further purification.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-996cda0112744b199945e3df153fe751
Source dataset
uspto-grants-2010_04
Patent number
US07700591B2

Reaction notes

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