Dichloromethane → 3,4,4-Trimethoxypiperidine

HRID 643726Notes

Reaction equation

HRID 643726 reaction equation
[CH3:1][O:2][CH:3]1[C:8]([O:11][CH3:12])([O:9][CH3:10])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.C(Cl)Cl.FC(F)(F)C(O)=O>>[CH3:1][O:2][CH:3]1[C:8]([O:11][CH3:12])([O:9][CH3:10])[CH2:7][CH2:6][NH:5][CH2:4]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 592630891-Boc-3,4,4-trimethoxypiperidine

Product 1

HCID 198835163,4,4-Trimethoxypiperidine

Procedure

The title compound was prepared by taking tert-butyl 3,4,4-trimethoxypiperidine-1-carboxylate (424 mg, 0.00154 mol) in Methylene chloride (10 mL, 0.2 mol) and adding Trifluoroacetic Acid (1 mL, 0.02 mol). The reaction was stirred for 3 h. The solvent was removed in vacuo and the crude taken to the next step (270 mg, 99%). MS calculated for C8H17NO3: (M+H) 176; found 176.1.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-cb10ae74227e4a48b1fbd9960c4da118
Source dataset
uspto-grants-2010_04
Patent number
US07700624B2

Reaction notes

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