Hydrochloric Acid → Ethyl 3-methoxy-4-oxopiperidine-1-carboxylate

HRID 643728Notes

Reaction equation

HRID 643728 reaction equation
[CH3:1][O:2][CH:3]1[C:8]([O:11]C)(OC)[CH2:7][CH2:6][N:5]([C:13]([O-:15])=[O:14])[CH2:4]1.CO.Cl.O1CCO[CH2:21][CH2:20]1>>[CH3:1][O:2][CH:3]1[C:8](=[O:11])[CH2:7][CH2:6][N:5]([C:13]([O:15][CH2:20][CH3:21])=[O:14])[CH2:4]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 866132863,4,4-Trimethoxypiperidine-1-carboxylate

Product 1

HCID 2724451Ethyl 3-methoxy-4-oxopiperidine-1-carboxylate

Procedure

The title compound was prepared by taking 3,4,4-trimethoxypiperidine-1-carboxylate (210 mg, 0.00085 mol) in Methanol (5 mL, 0.1 mol) and adding 4 M of Hydrogen chloride in 1,4-dioxane (5 mL). The reaction was allowed to stir for 4 h at ambient temperature. The residue obtained by removing the solvent in vacuo was used in the next step as-is (170 mg, 99%). MS calculated for C9H15NO4: (M+H) 202; found 202.1.

Workup

  1. customThe residue obtained
  2. customby removing the solvent in vacuo

Sources & evidence

ORD record
ord-57f1dff849444a4a8bdd1ee352ccdd46
Source dataset
uspto-grants-2010_04
Patent number
US07700624B2

Reaction notes

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