Trifluoroacetic acid → HCID 66750557, compound

HRID 643875Notes

Reaction equation

HRID 643875 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[N:19]1[CH2:23][C:22](=[O:24])[NH:21][S:20]1(=[O:26])=[O:25])[CH:15]=[C:14]([C:27]1[CH:28]=[C:29]([CH2:33][C:34]([OH:36])=[O:35])[CH:30]=[CH:31][CH:32]=1)[CH:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:37](O)([C:39](F)(F)F)=O>CCO>[CH2:37]([O:35][C:34](=[O:36])[CH2:33][C:29]1[CH:30]=[CH:31][CH:32]=[C:27]([C:14]2[CH:13]=[CH:12][C:11]3[C:16](=[CH:17][C:18]([N:19]4[CH2:23][C:22](=[O:24])[NH:21][S:20]4(=[O:26])=[O:25])=[C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH:10]=3)[CH:15]=2)[CH:28]=1)[CH3:39]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66750580HCID 66750580, compound

Product 1

HCID 66750557HCID 66750557, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of {3-[6-benzyloxy-7-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-naphthalen-2-yl]-phenyl}-acetic acid (600 mg, 1.2 mmol) in EtOH (50 mL) is added TFA (25 mL) and the mixture is heated at 40° C. for 2 h. EtOH and TFA are removed via vacuum and the residue is purified by HPLC to give the title compound.

Workup

  1. customEtOH and TFA are removed via vacuum
  2. customthe residue is purified by HPLC

Sources & evidence

ORD record
ord-7ca29fb5c49544d59c77a6349410b3fe
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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