反应详情

To a solution of 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (8.24 g) and triethylsilane (9.2 mL, 74 mmol) in DCM (100 mL) at 0° C. is added boron trifloride-diethyl etherate (17.6 mL, 110 mmol) drop wise. After stirring for 10 min, the mixture is warmed to RT and stirred for 30 min. 10% K2CO3 solution is added and it is extracted with EtOAc. The organic layer is washed with brine, dried with MgSO4 and concentrated to give the title compound as a yellow oil, which is then used in the next step without purification.

1. stirringstirred for 30 min
2. extractionit is extracted with EtOAc
3. washThe organic layer is washed with brine
4. dry with materialdried with MgSO4
5. concentrationconcentrated