HCID 66750744, compound → HCID 66750617, compound

HRID 643918Notes

Reaction equation

HRID 643918 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[N+:19]([O-])=O)[CH2:15][CH:14]([CH2:22][CH3:23])[CH2:13][CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pt]>[CH2:1]([O:8][C:9]1[C:18]([NH2:19])=[CH:17][C:16]2[CH2:15][CH:14]([CH2:22][CH3:23])[CH2:13][CH2:12][C:11]=2[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 66750744HCID 66750744, compound

Product 1

HCID 66750617HCID 66750617, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

To a solution of 6-benzyloxy-2-ethyl-7-nitro-1,2,3,4-tetrahydronaphthalene (490 mg, 1.57 mmol) is added 5% Pt/C (680 mg) and stirred under hydrogen atmosphere (1 atm) for 18 h. It is then filtered through Celite and the filtrate is concentrated. The residue is purified by column chromatography to give the title compound as a brown solid.

Workup

  1. filtrationIt is then filtered through Celite
  2. concentrationthe filtrate is concentrated
  3. customThe residue is purified by column chromatography

Sources & evidence

ORD record
ord-987ea5962c44468b82c8ecf8cb185750
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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