Trifluoroacetic acid → HCID 66750776, compound

HRID 643926Notes

Reaction equation

HRID 643926 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([N:19]2[S:23](=[O:25])(=[O:24])[N:22](CC3C=CC(OC)=CC=3OC)[C:21](=[O:37])[CH2:20]2)=[CH:11][C:12]2[CH2:16][CH:15]([CH3:17])[S:14][C:13]=2[CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[C:10]([N:19]2[S:23](=[O:24])(=[O:25])[NH:22][C:21](=[O:37])[CH2:20]2)=[CH:11][C:12]2[CH2:16][CH:15]([CH3:17])[S:14][C:13]=2[CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66750652HCID 66750652, compound

Product 1

HCID 66750776HCID 66750776, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-(6-benzyloxy-2-methyl-2,3-dihydrobenzo[b]thiophen-5-yl)-2-(2,4-dimethoxybenzyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (71 mg, 0.13 mmol) in DCM (8 mL) is added TFA (10 mL) and the mixture is stirred at RT for 4 h. TFA and DCM are removed under vacuum to give the title compound and it is used directly in the next step: (M+H)+=301.

Workup

  1. customTFA and DCM are removed under vacuum

Sources & evidence

ORD record
ord-fbf23991cbc0476d95c8e9064e06eaf9
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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