反应详情

To a solution of 2.5 g of methyl 5-[(2-fluorobenzyl)oxy]-6-nitronicotinate in 25 ml of THF were added 50 ml of ethanol, 25 ml of water, 218 mg of ammonium chloride, and 1.37 g of iron, followed by heating to reflux for 2 hours. After leaving to be cooled at room temperature, the reaction mixture was filtered over Celite, and to the filtrate were added a saturated aqueous sodium hydrogen carbonate solution and chloroform to carry out a layer separation operation. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to obtain 2.25 g of methyl 6-amino-5-[(2-fluorobenzyl)oxy]nicotinate.

1. temperatureby heating
2. temperatureto reflux for 2 hours
3. customAfter leaving
4. filtrationthe reaction mixture was filtered over Celite
5. additionto the filtrate were added a saturated aqueous sodium hydrogen carbonate solution and chloroform
6. customa layer separation operation
7. dry with materialThe organic layer was dried over anhydrous sodium sulfate
8. customthe solvent was evaporated under reduced pressure