反应详情

温度

40 °C

To a water (2.3 mL) suspension of 1.0 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine were added 0.72 g of hydrochloric acid, 6 mL of 2-propanol, and 0.5 mL of water at room temperature, which was then stirred at 40° C. Thereto was added 9 mL of 2-propanol, which was then stirred under cooling with ice for one hour. The precipitated crystals were collected by filtration to provide 1.4 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine trihydrochloride pentahydrate as colorless crystals. These crystals were used as seed crystals.

1. stirringwas then stirred
2. temperatureunder cooling with ice for one hour
3. filtrationThe precipitated crystals were collected by filtration