Potassium Carbonate → HCID 57860852, compound

HRID 644198Notes

Reaction equation

HRID 644198 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:37]=[C:36](F)[CH:35]=[CH:34][C:13]=1[C:14]([NH:16][C:17]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:18]=1[C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][N:23]=1)=[O:20])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:39]([O-:42])([O-])=O.[K+].[K+]>N1CCOCC1>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:37]=[C:36]([N:8]2[CH2:6][CH2:39][O:42][CH2:10][CH2:9]2)[CH:35]=[CH:34][C:13]=1[C:14]([NH:16][C:17]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:18]=1[C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][N:23]=1)=[O:20])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 68530931HCID 68530931, compound

Product 1

HCID 57860852HCID 57860852, compound

Reagents, catalysts & solvents 1

HCID 8083MorpholineSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-[2-(2-tert-butoxycarbonylaminoethoxy)-4-fluorobenzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide (0.8 g, 1.5 mmol), morpholine (10 mL), and K2CO3 (0.2 g) was heated in a sealed tube at 100° C. for 12 hours and then 120° C. for 4 h.

Workup

  1. custom120° C.
  2. customfor 4 h.

Sources & evidence

ORD record
ord-21920d70d5eb46f6b6722c99e6fdb589
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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