HRID644198

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CC(C)(C)OC(=O)NCCOc1cc(F)ccc1C(=O)Nc1ccc(F)cc1C(=O)Nc1ccc(Cl)cn1

HCID68530931

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCCOc1cc(N2CCOCC2)ccc1C(=O)Nc1ccc(F)cc1C(=O)Nc1ccc(Cl)cn1

HCID57860852

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8083

Morpholine

C4H9NO

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

A mixture of 2-[2-(2-tert-butoxycarbonylaminoethoxy)-4-fluorobenzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide (0.8 g, 1.5 mmol), morpholine (10 mL), and K2CO3 (0.2 g) was heated in a sealed tube at 100° C. for 12 hours and then 120° C. for 4 h.

WORKUP

后处理

custom120° C.
customfor 4 h.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-21920d70d5eb46f6b6722c99e6fdb589
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:37]=[C:36](F)[CH:35]=[CH:34][C:13]=1[C:14]([NH:16][C:17]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:18]=1[C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][N:23]=1)=[O:20])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:39]([O-:42])([O-])=O.[K+].[K+]>N1CCOCC1>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:37]=[C:36]([N:8]2[CH2:6][CH2:39][O:42][CH2:10][CH2:9]2)[CH:35]=[CH:34][C:13]=1[C:14]([NH:16][C:17]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:18]=1[C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][N:23]=1)=[O:20])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2]