2-Chloro-4-nitroaniline → HCID 57860813, compound

HRID 644262Notes

Reaction equation

HRID 644262 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[NH:18][C:19](=[O:49])[C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[NH:27][C:28](=[O:48])[C:29]1[CH:34]=[CH:33][C:32]([N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[CH:31][C:30]=1[O:40][CH:41]1[CH2:46][CH2:45][N:44]([CH3:47])[CH2:43][CH2:42]1.FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.ClC1C=C([N+]([O-])=O)C=CC=1N>>[Cl:8][C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[NH:18][C:19](=[O:49])[C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[NH:27][C:28](=[O:48])[C:29]1[CH:34]=[CH:33][C:32]([N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[CH:31][C:30]=1[O:40][CH:41]1[CH2:46][CH2:45][N:44]([CH3:47])[CH2:43][CH2:42]1

Participants

4

Reactant 3

HCID 84922-Chloro-4-nitroanilineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 68534983HCID 68534983, compound

Product 1

HCID 57860813HCID 57860813, compound

Procedure

Using methods substantially equivalent to those described in Example 118, N-(2-chloro-4-nitrophenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 2-chloro-4-nitroaniline.

Sources & evidence

ORD record
ord-6c1e7b113bd047c2b4cc4238ba31405d
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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