ethyl (R)-2-acetylamino-3-(3,4-diethyl-phenyl)-propionate → (2R)-2-Amino-3-(3,4-diethylphenyl)propanoic acid

HRID 644313Notes

Reaction equation

HRID 644313 reaction equation
C([NH:4][C@H:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH3:19])=[C:14]([CH2:20][CH3:21])[CH:13]=1)[C:6]([O:8]CC)=[O:7])(=O)C>Cl>[NH2:4][C@H:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH3:19])=[C:14]([CH2:20][CH3:21])[CH:13]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 1

HCID 69711472ethyl (R)-2-acetylamino-3-(3,4-diethyl-phenyl)-propionate

Product 1

HCID 45095428(2R)-2-Amino-3-(3,4-diethylphenyl)propanoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 13.8 g (47.4 mmol) ethyl (R)-2-acetylamino-3-(3,4-diethyl-phenyl)-propionate and 160 mL 6 M HCl was refluxed in the oil bath for 3 h. The reaction mixture was cooled in the ice bath and the precipitate formed was suction filtered.

Workup

  1. temperaturewas refluxed in the oil bath for 3 h
  2. customthe precipitate formed
  3. filtrationfiltered

Sources & evidence

ORD record
ord-5a42f67f08a7462f892b1654d621e1b6
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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