Sodium Hydroxide → 5-Acetyl-2-(benzyloxy)benzoic acid

HRID 644406ノート

反応式

HRID 644406 の反応式
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[OH-].[Na+]>CO.O1CCCC1>[C:10]([C:8]1[CH:7]=[CH:6][C:5]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:4]([CH:9]=1)[C:3]([OH:21])=[O:2])(=[O:12])[CH3:11]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12368981Benzoic acid, 5-acetyl-2-(phenylmethoxy)-, methyl ester

生成物 1

HCID 218806135-Acetyl-2-(benzyloxy)benzoic acid収率 91%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

5-Acetyl-2-benzyloxybenzoic acid methyl ester (5.69 g, 20 mmol) was dissolved in a mixed solvent of methanol (20 mL) and tetrahydrofuran (20 mL). 2N Sodium hydroxide (11 mL) was added dropwise, and the mixture was stirred for 8 hours. The solvent was evaporated under reduced pressure. 2N Hydrochloric acid was added to the residue, and it was extracted with dichloromethane. After the dichloromethane layer was washed with water and brine, dried over anhydrous magnesium sulfate and concentrated, the residue was washed with isopropyl ether to give the title compound (4.92 g, 91.0%) as a white solid.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. addition2N Hydrochloric acid was added to the residue, and it
  3. extractionwas extracted with dichloromethane
  4. washAfter the dichloromethane layer was washed with water and brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated
  7. washthe residue was washed with isopropyl ether

出典と根拠

ORDレコード
ord-16184d0d58e043d28a4638ba60c5cc1b
出典データセット
uspto-grants-2010_04
特許番号
US07700655B2

反応ノート

読み込み中…