Dimethylamine → HCID 11165474, compound

HRID 644521Notes

Reaction equation

HRID 644521 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:20]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][N:28]3[CH2:33]COC[CH2:29]3)[CH:22]=2)[C:9]2[N:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:11]=[N:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2].C(OC(C1C=C(C2C=CC=C(CCl)C=2)C2N(C3C=CC=CC=3)C=NC=2C=1)=O)C.CNC>CN(C)C=O>[CH2:1]([O:3][C:4]([C:6]1[CH:20]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][N:28]([CH3:29])[CH3:33])[CH:22]=2)[C:9]2[N:10]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:11]=[N:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 11154930HCID 11154930, compoundHCID 67485331HCID 67485331, compound

Product 1

HCID 11165474HCID 11165474, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This was prepared analogously to 5-Ethoxycarbonyl-7-(3-(morpholin-4-yl-methyl)phenyl)-1-phenylbenzimidazole from 5-ethoxycarbonyl-7-(3-(chloromethyl)phenyl)-1-phenylbenzimidazole (0.50 g, 1.28 mmol) and dimethylamine (approximately 2 ml) in anhydrous dimethylformamide (5 ml). The crude product was triturated in diethyl ether to afford the title product as an off-white solid (0.139, 25%) m/z, 400.2 (M+H)+.

Workup

  1. customThe crude product was triturated in diethyl ether

Sources & evidence

ORD record
ord-aa97aee4df4f40b89c1cb9e3401bbc4d
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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