反应详情

A mixture of succinic acid (Alfa-Aesar, 149.00 g, 1.26 mol), 2-octanol (Alfa-Aesar, 350.00 g, 2.69 mol), toluene (625 mL), and methanesulfonic acid (Alfa-Aesar, 2.00 g, 21 mmol) was heated to reflux for 6 hours. The water liberated was collected in a Dean Stark trap. The mixture was cooled, washed with saturated sodium bicarbonate (300 mL) and brine (100 mL), and dried over magnesium sulfate. The solvent was removed under vacuum to give a yellow oil that was used without further purification (426.39 g).

1. temperaturewas heated
2. temperatureto reflux for 6 hours
3. customThe water liberated was collected in a Dean Stark trap
4. temperatureThe mixture was cooled
5. washwashed with saturated sodium bicarbonate (300 mL) and brine (100 mL)
6. dry with materialdried over magnesium sulfate
7. customThe solvent was removed under vacuum
8. customto give a yellow oil that
9. customwas used without further purification (426.39 g)