N,N-Dimethyl-1,3-propanediamine → HCID 86718958, compound

HRID 64528Notes

Reaction equation

C([NH:4][C@H:5]([C:21]([O:23]C(=O)[C@H](CCCCNC(OCC1C=CC=CC=1)=O)NC(O)=O)=[O:22])[CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])(O)=[O:2].C([NH:49][C@@H:50]1[C:56](=[O:57])[O:55][C:53](=[O:54])[CH:52]([CH3:58])[CH2:51]1)(O)=O.CN(C)CCCN>ClCCCl>[CH3:58][CH:52]([C:53]([OH:54])=[O:2])[CH2:51][C@@H:50]([C:56]([OH:55])=[O:57])[NH2:49].[CH2:14]([O:13][C:11]([NH:10][CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]([C:21]([OH:23])=[O:22])[NH2:4])=[O:12])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

Conditions

Temperature: 25 °C

Procedure

To 1,2-dichloroethane (130 ml) were added Nα-carboxy-Nε-benzyloxycarbonyl-L-lysine anhydride (4.02 g, 13.12 mmol) and N-carboxy-γ-methyl-L-glutamic acid anhydride (2.46 g, 13.12 mmol), N,N-dimethyl-1,3-propanediamine (32.78 μl, 0.262 mmol) was added as an initiator, and the mixture was stirred at 25° C. for 1 day to give a γ-methyl-L-glutamic acid/Nε-benzyloxycarbonyl-L-lysine copolymer. The weight average molecular weight, Mw, of the copolymer was measured by Measurement Method 1 described below. In addition, the composition of the copolymer was measured by Measurement Method 2 described below.

Workup

additionwas added as an initiator

Sources & evidence

ORD record: ord-d050597d77bf46f7abe789dce4238216
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09450174B2

Reaction notes

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