反应详情

A three neck round bottom flask was charged with 2,6-diisopropylaniline (22.96 g, 130 mmol) and DMF (Volume: 250 ml). A solution of 1-bromopyrrolidine-2,5-dione (23.05 g, 130 mmol) in 100 ml DMF was added into reaction mixture drop wise at 0° C. After addition was over; reaction mixture was stirred for 2 days at room temperature. The reaction mixture was poured into 500 ml deionized water and extracted with 3×150 ml ether. The combined extracts were washed with 150 ml deionized water, 150 ml 10% lithium chloride, dried over MgSO4 and evaporated to dryness. The residue was purified by vacuum distillation to yield 4-bromo-2,6-diisopropylaniline (32.3 g; 97%).

1. additionAfter addition
2. customreaction mixture
3. additionThe reaction mixture was poured into 500 ml
4. extractionextracted with 3×150 ml ether
5. washThe combined extracts were washed with 150 ml
6. dry with materialdried over MgSO4
7. customevaporated to dryness
8. distillationThe residue was purified by vacuum distillation