Hydrochloric Acid → HCID 86082276, compound

HRID 645591Notes

Reaction equation

HRID 645591 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][C:8]2=O)=[CH:4][CH:3]=1.Cl.[O:13]([NH2:15])[CH3:14]>N1C=CC=CC=1.C(OC(=O)C)C>[CH3:14][O:13][N:15]=[C:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:10]=2)[CH2:6][CH2:7]1

Participants

6

Reactant 3

HCID 313Hydrochloric Acid2×HCID 4113O-MethylhydroxylamineHCID 15194646-Fluoro-1-indanone

Product 1

HCID 86082276HCID 86082276, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 6-fluoro-indan-1-one (0.5 g, 3.33 mmol) in pyridine (10 ml) was added the HCl salt of methoxylamine (0.31 g, 3.66 mmol) and stirred at room temperature for overnight. The reaction mixture was diluted with ethylacetate (50 ml), acidified with 3N HCl, and washed with 1N HCl, water and brine sequentially. The solution was dried (Na2SO4) and concentrated to yield 0.48 g (81%) of product. MS (ESI+) m/z 180 (M+H)+;

Workup

  1. washwashed with 1N HCl, water and brine sequentially
  2. dry with materialThe solution was dried (Na2SO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-9e19584376984926b34a50bc55d0975f
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

Loading…