Ethyl 5-aminocarbonyl-4,6-dimethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate → HCID 13726807, compound

HRID 64572Notes

Reaction equation

HRID 64572 reaction equation
[NH2:1][C:2]([C:4]1[C:5]([O:21][CH3:22])=[C:6]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]([C:12]([F:15])([F:14])[F:13])=[N:8][C:9]=1[O:10][CH3:11])=O>O=P(Cl)(Cl)Cl>[C:2]([C:4]1[C:5]([O:21][CH3:22])=[C:6]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]([C:12]([F:15])([F:13])[F:14])=[N:8][C:9]=1[O:10][CH3:11])#[N:1]

Participants

3

Reactant 1

HCID 13726804Ethyl 5-aminocarbonyl-4,6-dimethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate

Product 1

HCID 13726807HCID 13726807, compoundYield 84.9%

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

This material was obtained in 84.9% yield from the product of Example 22 (0.014 mol) and 100 ml of POCl3 by a procedure similar to that in Example 24 as a solid: mp 32°-34° C.

Sources & evidence

ORD record
ord-e12071271bcf433eb2bc478899e6d6fb
Source dataset
uspto-grants-1986_09
Patent number
US04609399

Reaction notes

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