Ethanesulfonyl chloride → 1-(Ethanesulfonyl)piperazine

HRID 645774Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:14]([S:16](Cl)(=[O:18])=[O:17])[CH3:15].CC1C(C(N2CCNCC2)=O)=C(C)ON=1>>[CH2:14]([S:16]([N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:18])=[O:17])[CH3:15]

Participants

Reactant 3

HCID 11667Ethanesulfonyl chloride

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 28776588(3,5-Dimethylisoxazol-4-yl)(piperazin-1-yl)methanone

Product 1

HCID 4152941-(Ethanesulfonyl)piperazine

Procedure

Ethanesulfonyl-piperazine was prepared from 1-tert-butyloxycarbonyl-piperazine and ethylsulfonyl chloride in an analogous manner as described for the preparation of (3,5-dimethyl-isoxazol-4-yl)-piperazin-1-yl-methanone in example 41.

Sources & evidence

ORD record: ord-c1b597e0535b463d87593649524fd503
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705007B2

Reaction notes

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