反应详情

Benzyl chloroformate (47 ml.) was added dropwise to a stirred solution of 3-aminopropanol (11.4 ml) in pyridine (150 ml) at 0°. The mixture was then stirred at room temperature overnight. This was poured into ice-water (300 ml.) and extracted with ethyl acetate (3×200 ml). The organic extract was washed with hydrochloric acid (5m, 3×400 ml), dried with anhydrous sodium carbonate-magnesium sulphate and evaporated to give the desired compound as an oil contaminated with a little dimethylcarbonate (30.23 g).

1. extractionextracted with ethyl acetate (3×200 ml)
2. extractionThe organic extract
3. washwas washed with hydrochloric acid (5m, 3×400 ml)
4. dry with materialdried with anhydrous sodium carbonate-magnesium sulphate
5. customevaporated