Thionyl Chloride → HCID 45923264, compound

HRID 646122Notes

Reaction equation

HRID 646122 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8](O)=[O:9])=[CH:4][CH:3]=1.O=S(Cl)[Cl:17]>CN(C=O)C>[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([Cl:17])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 3448942-(4-Bromophenoxy)-2-methylpropanoic acid

Product 1

HCID 45923264HCID 45923264, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-(4-bromophenoxy)-2-methylpropanoic acid (10.0 g, 38.6 mmol). DMF (0.5 mL) and SOCl2 (40 mL) was heated for 3 h, allowed to cool and distilled to yield the sub-title compound (8.4 g, 78%).

Workup

  1. temperatureto cool
  2. distillationdistilled

Sources & evidence

ORD record
ord-d78c7287691f4c90ba67b6ddc78af454
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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