Tetrahydrofuran → HCID 21186339, compound

HRID 646129Notes

Reaction equation

HRID 646129 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8](O)=[O:9])=[CH:4][CH:3]=1.C1COCC1>>[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:11])([CH3:12])[CH2:8][OH:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 3448942-(4-Bromophenoxy)-2-methylpropanoic acid

Product 1

HCID 21186339HCID 21186339, compoundYield 85%

Procedure

The sub-title compound was prepared by reduction of 2-(4-bromophenoxy)-2-methylpropanoic acid (2 g, 7.7 mmol) with BH3×THF (1M, 27.0 mmol, 27.0 mL) in accordance with the procedure described in Example 29(b). Distillation under reduced pressure gave the sub-title compound (1.60 g, 85%).

Workup

  1. distillationDistillation under reduced pressure

Sources & evidence

ORD record
ord-ed1c25f473c1460c94f17a383a716c67
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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