反应详情

The title compound is prepared in a manner substantially analogous to General Procedure D in 10 mL 10% DMF/dichloromethane using 4-(5-dimethylcarbamoyl-thiophen-2-yl)-benzoic acid (88 mg, 0.32 mmol), EDC-HCl (86 mg, 0.45 mmol), HOBt (61 mg, 0.45 mmol), DIEA (0.14 mL, 0.80 mmol) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine (46 mg, 0.30 mmol) to give the title compound (100 mg, 81% yield). MS (ES+) 412.3 (M+H)+