Benzylamine → N-benzyl-5-bromonicotinamide

HRID 646694노트

반응식

HRID 646694 반응식
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[Br:1][C:2]1[CH:10]=[C:6]([C:7]([NH:18][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])[CH:5]=[N:4][CH:3]=1

참가 물질

3

반응물 2

HCID 7504BenzylamineHCID 887075-Bromonicotinic acid

생성물 1

HCID 835760N-benzyl-5-bromonicotinamide수율 90%

실험 절차

5-bromo-N-(phenylmethyl)pyridine-3-carboxamide was synthesized according to the procedure described above from 5-bromonicotinic acid and benzylamine. Yield 90%. 1H NMR (400 MHz, CDCl3): 8.83 (d, 1H), 8.72 (d, 1H), 8.25 (t, 1H), 7.30 (m, 5H), 6.58 (br s, 1H), 4.62 (d, 2H); MS (EI) for C13H11N2OBr: 291 (MH+).

출처 및 근거

ORD 기록
ord-e8d645be75714ff194efb8a3b7068456
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704995B2

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