O-Phenylenediamine → HCID 68650316, compound

HRID 646714Notes

Reaction equation

HRID 646714 reaction equation
[NH2:1][C:2]1[C:3]([C:16]([NH:18][CH3:19])=[O:17])=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]=O)[CH:9]=2)=[CH:6][N:7]=1.[C:20]1([NH2:27])[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[NH2:26]>CN1C(=O)CCC1>[NH2:1][C:2]1[C:3]([C:16]([NH:18][CH3:19])=[O:17])=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]3[NH:27][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[N:26]=3)[CH:9]=2)=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 7243O-PhenylenediamineHCID 58710602HCID 58710602, compound

Product 1

HCID 68650316HCID 68650316, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of 3-amino-6-(3-formylphenyl)-N-methylpyrazine-2-carboxamide (25.4 mg, 0.1 mmol) and 1,2-phenylendiamine in NMP (3 mL) was heated at 80° C. for 8 h. The solvent was removed and the residue was triturated with 0.1 M aquous hydrochloric acid.

Workup

  1. customThe solvent was removed
  2. customthe residue was triturated with 0.1 M aquous hydrochloric acid

Sources & evidence

ORD record
ord-965ad633130f4f1abb397cba5c65c3a5
Source dataset
uspto-grants-2010_04
Patent number
US07704995B2

Reaction notes

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