Ethyl Acetate → HCID 68679561, compound

HRID 646886Notes

Reaction equation

HRID 646886 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[CH:5]=[N:4][C:3]=1[N+:15]([O-:17])=[O:16].CN1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.[CH3:25][CH2:26]OC(C)=O>>[CH3:14][N:11]1[CH2:12][CH2:13][N:8]([C:6]2[CH:5]=[N:4][C:3]([N+:15]([O-:17])=[O:16])=[C:2]([N:22]3[CH2:23][CH2:24][CH:25]([CH3:26])[CH2:20][CH2:21]3)[N:7]=2)[CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 531671-MethylpiperazineHCID 86604894HCID 86604894, compound

Product 1

HCID 68679561HCID 68679561, compoundYield 96%

Procedure

To 6′-chloro-4-methyl-5′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (32 mg, 0.12 mmol) was added N-methylpiperazine (370 mg, 3.7 mmol) and the resultant solution was stirred for 15 min. The reaction was diluted with EtOAc (50 mL), washed with H2O (2×20 mL), dried (K2CO3) and concentrated in vacuo to afford 37 mg (96%) of the title compound. Mass spectrum (ESI, m/z): Calcd. for C15H24N6O2, 321.2 (M+H), found 321.1.

Workup

  1. washwashed with H2O (2×20 mL)
  2. dry with materialdried (K2CO3)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b2f51cdfa09e4216a42a8a5c1629e546
Source dataset
uspto-grants-2010_04
Patent number
US07705042B2

Reaction notes

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