反应详情

To a mixture of 2 moles (248.26 g.) of 2-methoxyphenol, 4 moles (160 g.) of sodium hydroxide, 250 ml. of water and 1 liter of isopropanol was added with stirring 2.2 moles (314.64 g.) of 1,4-dichloro-2-butanol. The mixture was refluxed gently overnight. The reaction mixture was extracted with 1 liter of isopropyl ether, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 136°-138° C./0.015 mm. (396.8 g.) solidified to a white crystalline solid which melted at 48°-50° C.

1. temperatureThe mixture was refluxed gently overnight
2. extractionThe reaction mixture was extracted with 1 liter of isopropyl ether
3. dry with materialdried over sodium sulfate
4. distillationdistilled under reduced pressure
5. distillationThe distillate which was collected at 136°-138° C./0.015 mm