Hydrazine hydrate (1:1) → 4-Hydrazino 7-trifluoromethyl-quinoline hydrochloride

HRID 647071Notes

Reaction equation

HRID 647071 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.O.[NH2:17][NH2:18]>C(O)C>[ClH:1].[NH:17]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1)[NH2:18]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 676684-Chloro-7-(trifluoromethyl)quinoline

Product 1

HCID 204855944-Hydrazino 7-trifluoromethyl-quinoline hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-chloro-7-trifluoromethylquinoline (21.95 g.) in ethanol (100 ml.) and hydrazine hydrate (60 g.) was refluxed overnight. The solvent and the excess of reagent were removed in vacuo to give 4-hydrazino-7-trifluoromethylquinoline hydrochloride.

Workup

  1. temperaturewas refluxed overnight
  2. customThe solvent and the excess of reagent were removed in vacuo

Sources & evidence

ORD record
ord-6f700dd3996a4c5086e6c4a914ac98e0
Source dataset
uspto-grants-1983_10
Patent number
US04407803

Reaction notes

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