Potassium Carbonate → HCID 12770718, compound

HRID 647248Notes

Reaction equation

HRID 647248 reaction equation
[C:1]([O:4][CH2:5][C:6](Cl)=[O:7])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH:15]([NH:18][O:19][CH2:20][CH2:21][O:22][CH2:23][CH3:24])([CH3:17])[CH3:16]>C(#N)C>[CH2:23]([O:22][CH2:21][CH2:20][O:19][N:18]([CH:15]([CH3:17])[CH3:16])[C:6](=[O:7])[CH2:5][O:4][C:1](=[O:3])[CH3:2])[CH3:24]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 26297Acetoxyacetyl chlorideHCID 12770714HCID 12770714, compound

Product 1

HCID 12770718HCID 12770718, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
30 °C

Procedure

27.3 g (0.2 mole) of 2-acetoxyacetyl chloride were added to a mixture of 33.1 g (0.24 mole) of potassium carbonate, 200 ml of acetonitrile and 29.4 g (0.2 mole) of N-isopropyl-O-(2-ethoxyethyl)-hydroxylamine. During this addition, the temperature increased to about 30° C. The reaction mixture was subsequently stirred for a further 2 hours, without cooling, and was filtered and the solvent was distilled off in vacuo. 38 g (77% of theory) of acetoxy-acetic acid N-(2-ethoxyethoxy)-N-isopropyl-amide were thus obtained in the form of a colourless oil with a boiling point of 106°-107° C./0.1 mm Hg.

Workup

  1. additionDuring this addition
  2. temperaturewithout cooling
  3. filtrationwas filtered
  4. distillationthe solvent was distilled off in vacuo

Sources & evidence

ORD record
ord-02b74a7dc7eb4dfbb85de1409a3ca3b8
Source dataset
uspto-grants-1983_10
Patent number
US04408055

Reaction notes

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