Benzyl chloroformate → Benzyl 4-(2-hydroxy-4-methoxybenzoyl)piperidine-1-carboxylate

HRID 647330Notes

Reaction equation

HRID 647330 reaction equation
[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5].C(=O)(O)[O-].[Na+].Cl[C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25]>ClCCl>[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([CH:6]1[CH2:7][CH2:8][N:9]([C:24]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:25])[CH2:10][CH2:11]1)=[O:5]

Participants

5

Reactant 3

HCID 10387Benzyl chloroformateHCID 516892Sodium BicarbonateHCID 13076390(2-Hydroxy-4-methoxyphenyl)(piperidin-4-yl)methanone

Product 1

HCID 13076396Benzyl 4-(2-hydroxy-4-methoxybenzoyl)piperidine-1-carboxylateYield 76.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred, ice-cooled mixture of 36.1 g of 4-(2-hydroxy-4-methoxybenzoyl)piperidine, 16.3 g of sodium bicarbonate and 350 ml of dichloromethane, was added dropwise 22.9 ml of benzyl chloroformate in dichloromethane. After the addition was complete, the mixture was stirred at ambient temperature for 1.5 hrs, filtered and the filtrate concentrated to an oil. The oil crystallized. The crystals were collected, washed with hexane and dried to yield 42.4 g (76.5%) of product. Recrystallization from isopropanol gave the analytical sample, mp, 89°-91°.

Workup

  1. temperatureTo a stirred, ice-cooled
  2. additionAfter the addition
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated to an oil
  5. customThe oil crystallized
  6. customThe crystals were collected
  7. washwashed with hexane
  8. customdried

Sources & evidence

ORD record
ord-cf482f77ad8e453bbfd2d564e8600eab
Source dataset
uspto-grants-1983_10
Patent number
US04408054

Reaction notes

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