HRID64747

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70297

Benzenecarboperoxoic acid, 3-chloro-

C7H5ClO3

结构：O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)C(C=C(Cl)Cl)=CS[C@H]12

HCID88625624

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=C(Cl)Cl)CS(=O)[C@H]12

HCID88625126

未命名化合物

收率 42.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

A solution of m-chloroperbenzoic acid (7 g) in ethyl acetate (35 ml) was added to a solution of benzhydryl 7-phenylacetamido-3-(2,2-dichlorovinyl)-2-cephem-4-carboxylate (15 g) in ethyl acetate (75 ml) under ice-cooling and the mixture was stirred at the same temperature for an hour. The precipitates were collected by filtration to give benzhydryl 7-phenylacetamido-3-(2,2-dichlorovinyl)-3-cephem-4-carboxylate-1-oxide (6.57 g).

WORKUP

后处理

temperaturecooling
filtrationThe precipitates were collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d28ec22631c49fbb7e9d1fa971a4369
来源数据集: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04609730
来源说明: uspto-grants-1986_09

反应 SMILES

ClC1C=CC=C(C(OO)=[O:9])C=1.[C:12]1([CH2:18][C:19]([NH:21][CH:22]2[C:49](=[O:50])[N:24]3[CH:25]([C:33]([O:35][CH:36]([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)[C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)=[O:34])[C:26]([CH:29]=[C:30]([Cl:32])[Cl:31])=[CH:27][S:28][C@H:23]23)=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(OCC)(=O)C>[C:12]1([CH2:18][C:19]([NH:21][CH:22]2[C:49](=[O:50])[N:24]3[C:25]([C:33]([O:35][CH:36]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)[C:43]4[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=4)=[O:34])=[C:26]([CH:29]=[C:30]([Cl:31])[Cl:32])[CH2:27][S:28](=[O:9])[C@H:23]23)=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1