Hydrochloric Acid → Hydrochloric Acid

HRID 647514Notes

Reaction equation

HRID 647514 reaction equation
C([NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])[N:12]=2)[CH2:7][CH2:6]1)(=O)C.[ClH:23]>>[ClH:23].[NH2:4][CH:5]1[CH2:6][CH2:7][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH2:18][C:19]([F:21])([F:22])[F:20])[N:12]=2)[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 129266194-Acetamido-1-[6-(2,2,2-trifluoro) ethoxy-2-pyridyl]piperidine

Product 2

HCID 313Hydrochloric AcidHCID 12760111HCID 12760111, compound

Procedure

By heating the 4-acetamido-1-[6-(2,2,2-trifluoro) ethoxy-2-pyridyl]piperidine at reflux for 3 hours in an 0.5 N solution of hydrochloric acid and then operating as described in Example 1, the monohydrochloride of 4-amino-1-[6-(2,2,2-trifluoro)ethoxy-2-pyridyl] piperidine (CM 57385) is obtained which, after crystallation in ethanol, melts at 218° to 225° C. with decomposition.

Sources & evidence

ORD record
ord-eea95c5ddc35469da0b268a02c0425cf
Source dataset
uspto-grants-1983_10
Patent number
US04409228

Reaction notes

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