反应详情

By heating the 4-acetamido-1-[6-(2,2,2-trifluoro) ethoxy-2-pyridyl]piperidine at reflux for 3 hours in an 0.5 N solution of hydrochloric acid and then operating as described in Example 1, the monohydrochloride of 4-amino-1-[6-(2,2,2-trifluoro)ethoxy-2-pyridyl] piperidine (CM 57385) is obtained which, after crystallation in ethanol, melts at 218° to 225° C. with decomposition.