Hydrochloric Acid → (2-Ethyl-1,6-dioxaspiro[4.5]decan-2-yl)methanol

HRID 647751Notes

Reaction equation

HRID 647751 reaction equation
[CH2:1]([C:3]1([O:13][CH2:12]1)[CH2:4][CH2:5][C:6]1[O:11][CH2:10][CH2:9][CH2:8][CH:7]=1)[CH3:2].Cl.C([O:17]CC)C>O1CCCC1>[CH2:1]([C:3]1([CH2:12][OH:17])[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][O:11]2)[O:13]1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132371796-[2-(2-Ethyloxiran-2-yl)ethyl]-3,4-dihydro-2H-pyran

Product 1

HCID 13237167(2-Ethyl-1,6-dioxaspiro[4.5]decan-2-yl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 5.5 g of 6-(3-ethyl-(3,4-epoxybutyl))-3,4-dihydro-2H-pyran was added a solution of 2 ml of 10% hydrochloric acid in 25 ml of tetrahydrofuran. The reaction mixture was stirred under nitrogen for five days and then poured into 150 ml of diethyl ether. The resulting solution was washed twice with 50 ml of saturated sodium bicarbonate solution, and dried, and the solvent was removed under high vacuum to yield 6 g of the desired product as a dark brown oil.

Workup

  1. washThe resulting solution was washed twice with 50 ml of saturated sodium bicarbonate solution
  2. customdried
  3. customthe solvent was removed under high vacuum

Sources & evidence

ORD record
ord-cadce283ebfd4e47ad7d3e5fa611f4d4
Source dataset
uspto-grants-1983_10
Patent number
US04410354

Reaction notes

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