Water → Pyrrol-2-yl-carbonyl-L-leucyl-glycinamide

HRID 64779Notes

Reaction equation

HRID 64779 reaction equation
C(N(CC)CC)C.[NH:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[C:13]([OH:15])=O.[NH2:16][C@H:17]([C:22]([NH:24][CH2:25][C:26]([NH2:28])=[O:27])=[O:23])[CH2:18][CH:19]([CH3:21])[CH3:20].O>O1CCOCC1>[NH:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[C:13]([NH:16][C@H:17]([C:22]([NH:24][CH2:25][C:26]([NH2:28])=[O:27])=[O:23])[CH2:18][CH:19]([CH3:20])[CH3:21])=[O:15]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 12473Pyrrole-2-Carboxylic AcidHCID 6993103Glycinamide, L-leucyl-

Product 1

HCID 53906830Pyrrol-2-yl-carbonyl-L-leucyl-glycinamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

7.0 ml of triethylamine and 10.4 g of the N-hydroxysuccinimide ester of pyrrole-2-carboxylic acid were added to 9.4 g of L-leucyl-glycinamide in 120 ml of dioxane at 10° C. and the reaction mixture was stirred for 2 hours at this temperature, after which 30 ml of water were added and the stirred mixture was allowed to react for 20 hours at room temperature.

Workup

  1. customto react for 20 hours at room temperature

Sources & evidence

ORD record
ord-5909ef2253f94ad1805d16a92c4d454f
Source dataset
uspto-grants-1986_09
Patent number
US04610818

Reaction notes

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