Piperidine → 4-Ethyl-5-[4-(1-piperidinyl)benzoyl]-2-imidazolidinone

HRID 647834Notes

Reaction equation

HRID 647834 reaction equation
[CH2:1]([CH:3]1[NH:7][C:6](=[O:8])[NH:5][CH:4]1[C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13](F)=[CH:12][CH:11]=1)[CH3:2].[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH2:1]([CH:3]1[CH:4]([C:9](=[O:17])[C:10]2[CH:15]=[CH:14][C:13]([N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:12][CH:11]=2)[NH:5][C:6](=[O:8])[NH:7]1)[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 204843625-Ethyl-4-(4-fluorobenzoyl)-2-imidazolidinone

Product 1

HCID 204843634-Ethyl-5-[4-(1-piperidinyl)benzoyl]-2-imidazolidinone

Procedure

A suspension of 10 g of 5-ethyl-4-(4-fluorobenzoyl)-2-imidazolidinone in 30 ml piperidine is stirred at reflux for 24 hours. Excess piperidine is evaporated under reduced pressure and the residue is purified by crystallization from alcohol.

Workup

  1. temperatureat reflux for 24 hours
  2. customExcess piperidine is evaporated under reduced pressure
  3. customthe residue is purified by crystallization from alcohol

Sources & evidence

ORD record
ord-4ddbf90ac6ac4b019dcfaf4b60cee3f7
Source dataset
uspto-grants-1983_10
Patent number
US04410540

Reaction notes

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