反应详情

2-Hydroxy-6-methoxybenzaldehyde (4.56 g, 0.03 M), methyl 3-bromomethylbenzoate (6.87 g, 0.03 M), anhydrous potassium carbonate (4.455 g), sodium iodide (0.18 g) and methanol (50 ml) were refluxed with stirring for 18 hr. The cooled reaction mixture was filtered and the solid washed well with methanol. The filtrate was evaporated to dryness and the residue triturated with 1 N sodium hydroxide solution. The solid was filtered off and washed with water to give methyl 3-(2-formyl-3-methoxyphenoxy)methylbenzoate, 3.27 g, 36%, m.p. 96°-97° C. from ethyl acetate/petrol.

1. customThe cooled reaction mixture
2. filtrationwas filtered
3. washthe solid washed well with methanol
4. customThe filtrate was evaporated to dryness
5. customthe residue triturated with 1 N sodium hydroxide solution
6. filtrationThe solid was filtered off
7. washwashed with water