反应详情

4 g of 5-hydrazinobenzothiophene hydrochloride, suspended in 100 ml of isopropanol, are combined with 2.8 ml of 1-methyl-4-piperidone hydrochloride under N2. The solution is brought to the boil and 10 ml of isopropanol saturated with HCl re added whilst the solution is hot. After boiling the mixture of 1/2 hour, the solvent is distilled off, the residue is treated with ammonia and the precipitate is filtered off and recrystallised from methanol. 9-Methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole of melting point 189° C. is obtained.

1. additionre added whilst the solution
2. additionthe mixture of 1/2 hour
3. distillationthe solvent is distilled off
4. additionthe residue is treated with ammonia
5. filtrationthe precipitate is filtered off
6. customrecrystallised from methanol