Acetic Acid → HCID 20484279, compound

HRID 647934Notes

Reaction equation

HRID 647934 reaction equation
Cl.[CH2:2]([O:9][C:10]([C:12]1[S:13][C:14]2[CH:21]=[CH:20][C:19]([NH:22]N)=[CH:18][C:15]=2[C:16]=1[CH3:17])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(O)(=O)C.[CH3:28][N:29]1[CH2:34][CH2:33][C:32](=O)[CH2:31][CH2:30]1>Cl>[CH3:17][C:16]1[C:15]2=[C:18]3[C:19](=[CH:20][CH:21]=[C:14]2[S:13][C:12]=1[C:10]([O:9][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)=[O:11])[NH:22][C:32]1[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][C:31]3=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 740491-Methyl-4-piperidoneHCID 70531542HCID 70531542, compound

Product 1

HCID 20484279HCID 20484279, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4.5 g of 5-hydrazino-3-methylbenzothiophene-2-carboxylic acid benzyl ester hydrochloride are suspended in a mixture of HCl and glacial acetic acid; after adding 3 ml of 1-methyl-4-piperidone, the reaction mixture is boiled for 3 hours. The solvent is then evaporated off and the residue is adjusted to pH 7.5, and worked up as described under Example 11. Melting point: 174° C.

Workup

  1. customThe solvent is then evaporated off

Sources & evidence

ORD record
ord-3a6d42986f8d47318b8ae91842fbf2b4
Source dataset
uspto-grants-1983_10
Patent number
US04410536

Reaction notes

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