Hydrochloric Acid → 9-Isopropyl-1-phenyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

HRID 647953Notes

Reaction equation

HRID 647953 reaction equation
Cl.[NH:2]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]=2[CH:18]=1)N.[CH:19]([N:22]1[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]1)([CH3:21])[CH3:20].Cl>C(O)(C)C>[CH:19]([N:22]1[CH2:27][CH2:26][C:25]2[NH:2][C:4]3[C:18]([C:24]=2[CH2:23]1)=[C:8]1[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][S:11][C:7]1=[CH:6][CH:5]=3)([CH3:21])[CH3:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 793131-(Isopropyl)-4-piperidoneHCID 204842955-Hydrazino-3-phenylbenzothiophene hydrochloride

Product 1

HCID 204843239-Isopropyl-1-phenyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The compound is formed analogously to that described in Example 40, from 13.8 g of 5-hydrazino-3-phenylbenzothiophene hydrochloride and 7.5 g of 1-isopropyl-4-piperidone by boiling the starting materials in 120 ml of isopropanol containing hydrogen chloride for 4 hours. Melting point: 204° C.

Workup

  1. customThe compound is formed analogously to

Sources & evidence

ORD record
ord-5abc680e82a146c0bd286cb29a30bc6a
Source dataset
uspto-grants-1983_10
Patent number
US04410536

Reaction notes

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